TRANSLATIONAL PHYSIOLOGY Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis
نویسندگان
چکیده
Harold R. Collard, Carolyn S. Calfee, Paul J. Wolters, Jin Woo Song, Sang-Bum Hong, Sandra Brady, Akitoshi Ishizaka,† Kirk D. Jones, Talmadge E. King, Jr., Michael A. Matthay, and Dong Soon Kim Departments of Medicine and Anesthesia and Cardiovascular Research Institute, University of California San Francisco, San Francisco; Department of Medicine, University of Ulsan, Seoul, South Korea; Department of Medicine, Keio University, Tokyo, Japan; and Department of Pathology, University of California San Francisco, San Francisco, California
منابع مشابه
Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
Little is known about the pathobiology of acute exacerbation of idiopathic pulmonary fibrosis (IPF), a condition that shares clinical and histopathological features with acute lung injury. Plasma biomarkers have been well studied in acute lung injury and have provided insight into the underlying disease mechanism. The objective of this study was to determine the plasma biomarker profile of acut...
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BACKGROUND Acute exacerbations of idiopathic pulmonary fibrosis are major causes of morbidity and mortality among patients with idiopathic pulmonary fibrosis. However, acute exacerbations remain unpredictable. The aim of this study was to investigate risk factors for acute exacerbations of idiopathic pulmonary fibrosis. METHODS We performed a retrospective cohort study of patients with idiopa...
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Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations bet...
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Acute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function. Intervening prior to the onset of a substantially increased inflammatory response may limit the associated damage to the airways. While a number of biomarker assays based on inflammatory markers have been developed, providing u...
متن کاملViral infection in acute exacerbation of idiopathic pulmonary fibrosis.
RATIONALE Idiopathic pulmonary fibrosis is a progressive, uniformly fatal interstitial lung disease. An acute exacerbation of idiopathic pulmonary fibrosis is an episode of acute respiratory worsening without an identifiable etiology. Occult viral infection has been proposed as a possible cause of acute exacerbation. OBJECTIVES To use unbiased genomics-based discovery methods to define the ro...
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تاریخ انتشار 2010